DefinePK

Abstract

The oral and buccal routes are widely recognized as the most convenient and patient-friendly methods of drug administration, offering ease of use, safety, and improved compliance. Buccal disintegrating tablets provide an advantage over conventional dosage forms, especially for patients who experience difficulty in swallowing, such as those with dysphagia, motion sickness, or neurological conditions. These tablets dissolve rapidly in saliva without the need for water, ensuring quick onset of action and ease of administration.
The present study focuses on the formulation and evaluation of buccal disintegrating tablets of Gabapentin, an anticonvulsant drug, using β-Cyclodextrin to enhance its solubility and stability. β-Cyclodextrin is a well-established pharmaceutical excipient known for improving the solubility of poorly water-soluble drugs through complexation. Various formulations were prepared using the direct compression method, and the tablets were evaluated for physicochemical parameters including disintegration time, drug release profile, and mechanical properties.
Among the different formulations tested, formulation F5 exhibited the most promising results, with rapid disintegration and a high drug release rate of 99.99%. The study concludes that β-Cyclodextrin-based buccal disintegrating tablets of Gabapentin are a viable alternative for enhancing bioavailability and improving patient compliance..