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Abstract

Objectives: To assess their impact on blood pressure control, cardiovascular risk factors, and adverse effect profiles in hypertension patients; also, to compare the efficacy and safety of Benidipine and Azelnidipine in the management of hypertension.
Methods: This observational, comparative study was carried out among Indian tertiary care hospital outpatient department attendees with hypertension. Assigned to either Benidipine or Azelnidipine as monotherapy or add-on treatment, eligible adult participants were Collected were baseline demographic, clinical, and laboratory data including blood pressure, serum uric acid, and lipid profile. To track blood pressure, evaluate effectiveness, and document side effects, patients were checked at set intervals. Blood pressure reduction, laboratory parameter improvement, and side effect incidence all determined effectiveness.
Results: Systolic and diastolic blood pressure was notably lowered by both benidipine and azelnidipine. Because of its triple calcium channel blocking action, benidipine exhibited extra renoprotective effects and a more sustained antihypertensive action. With extra advantages for insulin resistance and anti-atherosclerotic properties, azelnidipine was also efficient and well tolerated. In both groups, adverse effects were minor and rare; no major incident was recorded.
Benidipine and azelnidipine are safe and effective antihypertensive medications. While Azelnidipine provides good blood pressure reduction with favorable metabolic effects, Benidipine may offer extra renal protection and sustained blood pressure control. Patient comorbidities and tolerance help one to customize their choice of drugs.