DefinePK

Abstract

Objective(s): This study aims to compare the safety outcomes in patients undergoing transurethral resection of the prostate (TURP) for benign prostatic hyperplasia (BPH) with prostate sizes above and below 80 grams.
Study Methodology: A retrospective cohort study was conducted at the Kidney Center Postgraduate Training Institute over a two-year period. The study included 291 patients aged 45 to 85 years who underwent TURP, with prostate sizes greater than 30 grams. An arbitrary size cutoff of 80 grams for prostrate size was used in our study. Patients were divided into two groups: Group A consisted of patients with prostates below 80 grams, while Group B included those with prostates above 80 grams. Pre- and post-operative hemoglobin levels, serum sodium levels and complications were analyzed using IBM SPSS version 21.0. Statistical significance was determined with a p-value ≤0.05.
Results: The mean prostate size for Group A was 53.4 ± 13.2 grams, and for Group B, 104.6 ± 24.8 grams. Both groups experienced a significant reduction in post-operative lab parameters, including hemoglobin and sodium levels (p < 0.001). However, Group B exhibited a significantly larger mean drop in hemoglobin (2.1 ± 1.3) compared to Group A (1.5 ± 1.1) (p < 0.001). Despite these differences in hemoglobin levels, other complications—such as the need for blood transfusions (p=0.415), sepsis (p= 0.999), and TUR syndrome (p= 0.651)—showed no significant differences between the groups.
Conclusions: TURP is a safe and effective treatment for BPH in patients with prostate sizes both above and below 80 grams. Despite a greater drop in hemoglobin in larger prostates, complication rates remain similar, making TURP a viable option for patients with larger prostates, especially in low-resource settings.