DefinePK

Abstract

Hydration plays a crucial role in maintaining renal function and overall homeostasis. Water intake directly affects kidney physiology, influencing the glomerular filtration rate (GFR), urine concentration, and excretion of metabolic waste products, including serum creatinine (Cr). Serum creatinine is a widely used biomarker for kidney function, with elevated levels often indicating impaired renal clearance and potential kidney dysfunction. While dehydration can lead to increased serum creatinine levels due to reduced renal perfusion and lower GFR, excessive water intake may also impact kidney function by altering electrolyte balance and inducing dilutional effects. This study will contribute to the growing body of literature by analyzing hydration status in relation to serum creatinine levels, thereby providing insights into the potential implications of water intake on renal health. The findings may have significant clinical implications for individuals at risk of kidney dysfunction, including those with pre-existing renal conditions, the elderly, and individuals exposed to chronic dehydration