DefinePK

Abstract

Imidazole derivatives are thought to be promising chemical substances that may have therapeutic efficacy against a number of dangerous pathogenic microorganisms. Molecular docking is an effective method in modern drug design to have greater comprehension of computational binding. New imidazole derivatives were designed for this investigation. Out of the designed compounds two derivatives, N1 (naphthalen-1-yl)-4,5-diphenyl-1H-imidazole) & N2 (2-(2-methylenaphthalen-1-yl)-4,5-diphenyl-1H-imidazole), exhibit good affinity for the active pocket of glucosamine-6-phosphate synthase (ID2VF5), according to the molecular docking studies. The compounds with a high binding affinity were synthesized by using a condensation reaction in the presence of a catalyst. IR and 1H NMR were used to confirm the synthesized compound's structure. By employing the cup & plate procedure, it was found that the synthesized imidazole derivatives exhibited antimicrobial activity toward both the Gram-positive organism Staphylococcus aureus and the Gram-negative organism Escherichia coli