DefinePK

Abstract

This study shows the successful creation of new hybrid nanomaterials by combining Bi(III) Schiff base complexes from nitro-Salen ligands with NiO nanoparticles. Spectroscopic techniques like FT-IR and UV-Vis confirmed strong coordination and improved optical properties, including a reduced band gap of 2.12 eV. XRD and FE-SEM analyses displayed porous, nanoscale structures with clear shapes. These hybrids showed strong interactions with serum proteins BSA, which was evident through fluorescence quenching and molecular docking, with a binding energy of –8.1 kcal/mol. Notably, the antibacterial activity of the hybrids increased significantly, especially when combined with Ampicillin. Overall, these results emphasize the potential of these multifunctional materials in biomedical uses like biosensing, targeted drug delivery, and antimicrobial treatments.