DefinePK

Abstract

Introduction: Since the 1960s, prostaglandins have been used extensively in clinical practice to induce labor; nevertheless, gastrointestinal symptoms, such as nausea, vomiting, and diarrhea, as well as uterine hyperstimulation and fever, have been documented as adverse effects. Numerous prostaglandin preparations have been administered orally, intramuscularly, intravenously, and locally (intravaginal and intracervical).
Methodology: From September 1, 2019, to February 1, 2020, the Department of Obstetrics and Gynecology at Ayub Teaching Hospital in Abbottabad undertook a descriptive case series to ascertain the frequency of cesarean sections among patients induced with the pill Prostein-E2 at term. The study comprised 155 pregnant women who were having labor induction. Dinoprostone tablets were given to each patient; three milligrams were injected enters the fornix of the posterior vagina. A third 3 mg tablet was administered when the cervix was favorable (Bishop score ± 8) after two more vaginal exams that were separated by six hours.
Results: The study's age range was 18–40 years old, with a mean gestational age of 27.903 ± 2.61 years of 38.071 ± 0.73 weeks, a mean number of doses of 1.335 ± 0.47, a mean parity of 1.419 ± 1.16, and a mean weight of 65.664 ± 4.77 Kg. Cesarean section was seen in 20% of patients.
Conclusion: Therefore, induction of labor in the presence of an immature cervix is linked to failure to progress labor, induction failure, and cesarean section risk.