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Optimized Production Assessment, Compartmental Modeling and Dosimetric Evaluation of 177Lu- PSMA-617 for Clinical Trials

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Title: Optimized Production Assessment, Compartmental Modeling and Dosimetric Evaluation of 177Lu- PSMA-617 for Clinical Trials

Authors: Mehdi Sharifi, Hassan Yousefnia, Ali Bahrami-Samani, Amir Reza Jalilian, Samaneh Zolghadri, Mahdokht Vaez-Tehrani, Stephan Maus

Journal: International journal of nuclear medicine research

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Publisher: Cosmos Scholars Publishing House

Year: 2017

Volume: 4

Issue: 2

Language: en

Keywords: biodistributionLu-177PSMA-617SPECT imagingCompartmental modeling.

Categories
Medical Physics (206) Pharmacokinetics (209) Nuclear Medicine (308) Radiology (9447) Oncology (10297)

Abstract

177Lu-PSMA-617 was prepared at the optimized conditions (95°C, 15-18 µg peptide, 35-40 min; solid phase purification) using 177Lu obtained from 176Lu(n, γ)177Lu reaction(>98%, ITLC, HPLC, S.A. 22-24 TBq/mM) followed by stability (up to 48 h), biodistribution studies (up to 168 h), planar imaging, compartmental modeling and dosimetry estimations via Sparks’s extrapolation method in human organs. Kidney is the critical organ with the dose of 0.067 mGy/MBq and the radiopharmaceutical can be safely used in trials considering the human dose.

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