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Abstract

Background and Objectives Diagnosing the onset of prostate cancer before the manifestation of symptoms is the challenge in detecting diseases. For intervention on the risk of cancer, this investigation assayed the in vitro estrogen elevation in mens population, by quantifying free Oestradiol and sex hormone-binding globulin level of selected men in Eket-Nigeria. Materials and Methods A 197 mens subjects were selected using a simplified sample size formula. Blood serum samples were prepared from the blood collected from the mens donors. The assay was carried out using estrogen E2 and sex hormone binding globulin SHBG, enzymes linked immunosorbent assay ELISA technique. The ratio of SHBG to E2 was calculated to get free oestradiol. Results A 28 of 197 men have elevated E2 beyond the recommended reference range 15-60 pg mL1501. This accounted for 14.21 of 28197 men with elevated free estrogen. Conclusion Comparing these figures with our control reference community where there was a low level of E2, one can infer that the men of Eket pose a risk of prostate cancer due to elevated E2. This implied that elevated testosterone is aromatized to estrogen by aromatase. Therefore, men of Eket should receive anti-estrogen therapy to reduce the risk of prostate cancer.