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Abstract

Background and Objective Pesticides have been implicated in oxidative stress, which is associated with many disorders, including testicular dysfunction. This study, therefore, investigated the ameliorative effect of coconut oil CCO on male Wistar rats exposed to propanil PPN, a commonly used herbicide. Materials and Methods The study comprised 4 groups of 5 rats each designated as control, CCO 2.7 mL kg1501, PPN 200 mg kg1501 and PPN 200 mg kg1501 CCO 2.7 mL kg1501. Rats were given their various treatments for 7 days and the ameliorative effect of CCO was assessed using antioxidant indices superoxide dismutase, glutathione-S-transferase, glutathione peroxidase, reduced glutathione and malondialdehyde levels. Results The study revealed that PPN exposure significantly p0.05 disturbed antioxidant status, increased lipid peroxidation LPO, alkaline phosphatase ALP and acid phosphatase ACP levels in testes of rats. Treatment with CCO, however, restored the depleted antioxidant status in rat testes, decreased LPO by 50.4 and reduced ALP activity by 19.6. Conclusion The results showed that testicular oxidative stress, a threat to male fertility induced by propanil exposure, could be attenuated by oral supplementation of coconut oil.