DefinePK

Abstract

Transition period is associated with important metabolic, nutritional and immune system changes. The combined effects of all these changes reduce production and increase culling rate that ultimately reduces profitability of farms. Therefore, the aim of this study was to know the potential interaction of these changes along with different predictive tools to evaluate these problems for the development of management strategy. In this review, metabolic, inflammatory and immune system changes in transition cow and its effect on health during the later postpartum period in dairy animals were discussed along with the integrative approaches at animal, cellular and molecular level using some predictive tools to unravel these complex interactions that predispose cows to periparturient diseases. This review is important as it showed that disregulatory immune function plays a key role for the incidence of several transition problems. Yet, reliable modern predictive tools can solve this issue to a huge extent as they have the ability to examine the immune and inflammatory status of individual transition dairy cows to clarify the intrinsic mechanism of peripartal disorders.