DefinePK

Abstract

Background and Objective Acrylamide is carcinogenic and mutagenic to experimental animals. Also, it has neurotoxic effect of animals and humans. The aim of study was to investigate the effects of different doses of acrylamide and black berry on free radicals and antioxidant enzyme activities in male rats. Materials and Methods Animals were assigned at random to one of the following treatments group 1 served as control, group 2 was treated with black berry juice 9 mL kg1501 b.wt., while groups 3, 4 and 5 were treated with 120, 600 and 1200 g kg1501 b.wt., of acrylamide, respectively in drinking water for 10 weeks. Groups 6, 7 and 8 were treated with those doses of acrylamide and black berry juice. Results The results showed that acrylamide increase thiobarbituric acid reactive substances TBARS, while decrease the activities of GSH and antioxidant enzyme Catalase, SOD, GST and GPX in liver, kidney, brain, lung and testes compared to control group. Black berry decrease of acrylamide risk. Conclusion The present results showed that different doses of acrylamide exerted deterioration effects on enzyme activities and free radicals in a dose-dependent manner. Black berry protection in all organs effects of acrylamide.