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Abstract

Background and Objective Blood contains low concentration of thiols and some thiols are found in the albumin compartment. So far, little or no information exists on the relationship between serum total thiols and albumin in sub-chronic lead intoxication. To examine the relationship between serum total thiols and albumin in sub-chronic lead intoxicated rats supplemented with folic acid andor vitamin C. Materials and Methods This study was performed using 40 male albino rats weighing 160-190 g. The albino rats were divided into eight 8 of five each. Group 1-4 were sub-chronically intoxicated with lead fora period of 6 weeks, followed by supplementation with folic acid andor vitamin C to group 2-7 fora period of 4 weeks. After the 10th week, the experimental rats were fasted overnight and sacrificed, after which their blood samples were collected. Results Findings from this study revealed statistically significant p0.05 decrease in serum total thiols and albumin concentration in the non-supplemented lead intoxicated group as compared to the level observed in the control group. Moreso, combined supplementation of folic acid and vitamin C modulates decreased in the total thiols and albumin concentration and both thiols and albumin correlates positively in the co-supplemented folic acid and vitamin C lead intoxicated group. Conclusion Co-supplementation of folic acid and vitamin C could be used as nutrient supplement to simultaneously restored depletion in serum total thiols and albumin concentrations of sub-chronic lead intoxication.