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Abstract

Background and Objective Metribuzin Triazinone herbicide is used worldwide as an ecotoxic herbicide and is the most widely used in Algeria and in random ways without respect for the doses approved. The objective of this study was to investigate the effects of pesticide on hematological and renal structure and function in rabbits. Materials and Methods About 15 pregnant female rabbits Oryctolagus cuniculus divided into three groups n 5, the first group of non-treated pregnant rabbits serve as control, the second group of pregnant rabbits treated with 3.22 mg kg1501 b.wt., of Metribuzin and the third group of pregnant rabbits treated with 6.44 mg kg1501 b.wt., of Metribuzin. Metribuzin added in their drinking water for 60 days before and during pregnancy. Results Results revealed a significant increase p0.05 in level of serum glucose, urea, creatinine, kidney MDA and kidney GST activity, white blood cell WBC, lymphocyte and Platelets PLT and decrease in GSH level, red blood cells RBC and hemoglobin HGB concentration in pregnant rabbits of both Metribuzin treatment groups as compared to the control. Also, the results clearly showed that Metribuzin causes alterations of glomerular and tubular structure in comparison with controls. Conclusion It is concluded that the pesticide-Metribuzin caused severe toxicity with tissue modification of the kidney which limits renal function and threatens fetal development in rabbits.