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Abstract

Background and Objective Propanil PRO is an acylanilide herbicide used to control barnyard grass and broad leaf weeds. This study evaluated the impact of PRO in streptozotocin STZ-induced diabetic rats. Materials and Methods Diabetes was induced in rats by a single injection of STZ 60 mg kg1501 intraperitoneal, i.p.. The PRO was administered at the dose of 200 mg kg1501 i.p. for 7 days, to both normal and diabetic rats. Results The plasma levels of triglyceride, aspartate aminotransferase, creatinine and renal malondialdehyde level an index of lipid peroxidation were significantly increased in diabetic rats. In addition, the levels of high density lipoprotein-cholesterol, superoxide dismutase were depressed in the STZ-treated rats compared to the control group. The co-exposure of PRO increased absolute organ weight, catalase, glutathione peroxidase and malondialdehyde levels. Conclusion Taken together, exposure to PRO exacerbated oxidative stress in renal tissue of diabetic rats.