DefinePK

Abstract

Background and Objective The rat and mouse models were generally used to screen the new compounds for the antidiabetic activity. There is a high need to discover the alternative animal models to reduce the cost of experimentation. This study, implemented the existed chick model for the screening of new compound for antidiabetic activity. The present study was aimed to evaluate the antidiabetic activity of selected indole derivative 1-4-Chlorobenzylidene-5-2-oxoindolin-3-ylidene thiocarbohydrazone using chick diabetes model. Methodology Diabetes was induced in chicks by administration of alloxan monohydrate on the 14th day of incubation at a dose of 0.9 mgegg, which was confirmed with birth of chicks with elevated blood glucose levels when compared with those of chicks without any alloxan treatment. One way ANOVA was used to analyze the data. Results After administration of test compound, it was found that the significant reduction in the glucose levels with a doses of 10 and 30 mg kg1501 doses. Conclusion Selected indole derivative 1-4-Chlorobenzylidene-5-2-oxoindolin-3-ylidene thiocarbohydrazone showed significant antidiabetic activity.