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Abstract

The effect of consumption of leaves of Solanum macrocarpon L. on the Prostate Specific Antigen PSA level, antioxidant status and hematological parameters in albino rats induced with Benign Prostate Hyperplasia BPH was studied. Twenty five animals divided into five experimental groups namely Normal Control group NC-group, Benign Prostate Hyperplasia group BPH-group, Finasteride-group, 5 Solanum macrocarpon-supplemented diet group 5 SMSD-group and 10 SMSD-group were used in the study. The NC was not induced with BPH and fed a control diet diet I. The BPH-group and Finasteride-group were induced with BPH but Finasteride-group was treated with finasteride and both were fed a control diet diet I. Five SMSD-group and 10 SMSD-group were induced with BPH and fed with 5 and 10 S. macrocarpon-Supplemented Diet SMSD, respectively. Benign prostate hyperplasia was induced in the animals by daily subcutaneous injections of Testosterone Propionate TP in olive oil for a period of 12 weeks and the animals were fed their respective diets throughout the duration. Parameters including Prostate Specific Antigen PSA, hematological indices including hemoglobin and white blood cells in vivo antioxidant markers such as Superoxide Dismutase SOD, Glutathione-S-Transferase GST, glutathione GSH and catalase were determined. The histo-pathological changes of the prostate were also examined. The results showed that PSA levels decreased significantly p0.05 in groups fed with SMSD. Superoxide dismutase SOD, Glutathione-S-Transferase GST and glutathione GSH levels increased significantly p0.05 while WBC were significantly decreased p0.05 in the groups fed SMSD. The histological studies showed a considerable improvement in the prostatic histo-architecture of the groups fed SMSD. These findings indicate that S. macrocarpon-supplemented diets may prevent or suppress the development of BPH and be useful in its treatment and management.