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Abstract

Antimicrobial resistance threatens the effective treatment of vast range of bacterial, fungi and viral diseases. Transmissible venereal tumour (TVT) is one of the highly contagious tumour in dogs commonly affecting sexually active stud and bitches. The disease was observed in a male and female Alsatian of about 3 years of age. Both dogs were sexually active and are utilized for breeding purposes. Samples were collected from the TVT growth on both the female and male genitalia. The samples were subjected to cytology and confirmatory diagnosis was made on the gross appearance of cauliformlike lesion and appearance of roundish cells with multiple vacuoles in the cytoplasm of the TVT tumour cells. Treatment was achieved by 3 doses of Vincristin sulphate injection USP1mg/ml Vinlon TM 1 intravenously through a cannula. There was no report of recrudesce of growth post treatment. Conclusion: TVT appear to exhibit genetic preference for sexually active Alsatian breed of dogs within the age bracket of 3 years and above.  Despite the confronting challenge of drug resistance in medicine, intravenous administration of vincristine sulphate has remained efficacious in achieving complete regression of TVT the growth in dogs.