DefinePK

Abstract

Rheumatoid arthritis (RA) is a chronic autoimmune disease that affects the joints and can lead to significant morbidity and loss of function. This study aims to evaluate the clinical profile, disease progression, and the impact of RA on patients attending a tertiary care center in Pakistan.
Methods:A prospective observational study was conducted between June 2024 to  December 27, 2024, at a teaching hospital in Pakistan. The study was a joint effort of the Departments of Medicine, Orthopedics, and Rheumatology. Patients diagnosed with RA, based on the American College of Rheumatology (ACR) 2010 criteria, were included. Data were collected through structured questionnaires and clinical assessments, focusing on demographic details, disease activity, symptoms, and extra-articular manifestations. Disease severity was measured using disease activity scores, and imaging and laboratory tests were performed to assess joint damage and inflammation.
Results:A total of 100 RA patients were enrolled. The most common symptoms included joint pain (100%), morning stiffness (95%), and joint swelling (93%). Extra-articular symptoms such as fever, joint deformities, and carpal tunnel syndrome were also observed in a smaller proportion of patients. Disease progression was noted, with increasing joint deformity and functional impairment. Laboratory tests showed elevated levels of inflammatory markers in active cases, confirming the diagnosis and severity of RA.
Conclusion:RA remains a prevalent and debilitating disease in Pakistan, with substantial effects on joint function and quality of life. The early diagnosis and appropriate management are crucial for improving long-term outcomes. Our study underscores the importance of integrated care, including rheumatology, orthopedics, and general medicine, to manage RA effectively. Further studies are needed to evaluate new diagnostic tools and therapeutic interventions to address the increasing burden of RA.