DefinePK

Abstract

Environmental and genetic factors are two of the variables that might affect cancer, making it a complex disease. Due to its rising incidence, cancer is tragically now the second leading cause of death globally, after heart disease. Chemotherapy's main goal is to prevent the cancer cells from proliferating. The medications can kill cancer cells faster and more efficiently than other surrounding cells because they multiply and spread dramatically more quickly than healthy cells and have extremely significant levels of endogenous stress. Non-coding RNAs (ncRNAs) are those that do not encode proteins. Numerous ncRNAs, such as long non-coding RNAs(lncRNAs), have been recognized as playing crucial parts in the initiation and spread of human malignancies. Drug resistance, the onset of BC, and the progression of metastases are all significantly influenced by long noncoding RNAs. Several examples of lncRNA and miRNA that show resistance to chemotherapy in different cancer types. This review discussed different types of ncRNAs, their mechanism of resistance to chemotherapy, lncRNAs and miRNAs that show resistance to chemotherapy, and the future strategies to overcome the resistance.