DefinePK

Abstract

Background:Chronic Obstructive Pulmonary Disease (COPD) is a progressive and debilitating respiratory condition characterized by airflow limitation. In Pakistan, COPD prevalence remains high, yet limited data exists on therapy-related challenges and patient outcomes. Understanding the real-world drug therapy implications is critical to improving care and reducing complications.
Aim:The primary aim of this study was to assess the prevalence of COPD and evaluate the rationality, safety, and effectiveness of current drug therapies administered at Khyber Teaching Hospital, Peshawar. The study also aimed to identify common drug-related problems (DRPs) in COPD management.
Methods: This observational, hospital-based study was conducted on 20 patients admitted to the pulmonology ward. Data were collected using a structured case history form, incorporating demographic details, clinical data, medication history, and laboratory investigations. Each case was assessed for treatment outcomes and drug-related problems such as adverse reactions, drug interactions, non-compliance, and therapeutic duplications.
Results:Out of 132 documented drug-related problems, the majority (71.96%) were due to drug-drug interactions. Adverse drug reactions accounted for 9.09%, untreated conditions 4.54%, and therapeutic duplication 2.27%. Common problematic drugs included dexamethasone, furosemide, and aminophylline. Despite some issues, overall therapy was considered rational, and most patients showed clinical improvement.
Conclusion:The study highlights a significant incidence of drug interactions and the need for enhanced monitoring and patient counseling. Improving pharmacological oversight and minimizing polypharmacy can optimize COPD outcomes in public hospital settings.