DefinePK

Abstract

Pharmaceutical jelly-based formulations represent a novel, emerging and patient-friendly approach in oral and mucosal drug delivery, contributing a palatable, semi-solid alternative to traditional tablets and capsules. Particularly advantageous for patient populations experiencing dysphagia, including pediatric and geriatric populations. Functioning at the intersection of liquid and solid dosage forms, these semi-solid systems facilitate enhanced palatability, ease of administration, and improved physicochemical stability of active pharmaceutical ingredients. This review critically explained the enriching research studies of jelly formulations, offering a systematic classification based on administration routes, therapeutic objectives, and compositional attributes. It further elucidates formulation strategies, excipient rationalization, and recent technological advancements supporting the development of fast-dissolving, sustained-release, and nutraceutical variants. Regulatory developments, formulation challenges, and emerging trends such as precision dosing and stimuli-responsive jellies are also addressed. Despite certain physicochemical properties and storage constraints, jelly systems exhibit considerable promise in improving medication adherence and optimizing therapeutic performance in contemporary pharmaceutics. Future directions indicate the development of advanced delivery systems utilizing nanotechnology, mucoadhesive polymers, and personalized medicine approaches. With increasing regulatory interest and market expansion, jelly formulations are poised to become a vital component of modern drug delivery systems.