DefinePK

Abstract

Background: Ischemic heart disease (IHD) is one of the main causes of death and illness, and platelet indices play a key part in how it works. Objective: To determine the frequency of IHD in patients presenting with chest pain and compare Mean Platelet Volume (MPV) and Platelet Count between IHD and non-IHD patients. Methodology: This descriptive case series was conducted at the Department of Cardiology & Internal Medicine, Mayo Hospital, Lahore, for the duration of three months from December 6, 2024 to March 5, 2025. Total 145 people between the ages of 18 and 65 who came in with chest pain were included. People with blood diseases, who were pregnant, or who were taking blood thinners were not allowed to participate.  Blood samples were tested for MPV and PC, and an independent t-test and chi-square test were used to compare the results statistically.  A p-value less than 0.05 was thought to be significant. Results: The average MPV was higher in people with IHD (10.7 ± 1.1 fl) than in people without IHD (9.5 ± 1.2 fl, p < 0.001).  The platelet count was much lower in people with IHD (212.4 ± 53.8 × 109/L) than in people without IHD (244.1 ± 49.2 × 109/L, p = 0.003).  Diabetes mellitus, high blood pressure, and smoking were all strongly linked to IHD (p = 0.002, p = 0.017, and p = 0.009, respectively). Conclusion: Elevated MPV and reduced platelet count are significantly associated with IHD, suggesting their potential role as biomarkers for cardiovascular risk assessment.