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Abstract

Objective: To determine the role of vitamin D supplementation on size of uterine leiomyomas in vitamin D deficient woman.
Methods: The study was conducted in the Department of Obstetrics and Gynaecology, Rawalpindi, from July 2019 to January 2020. This was a quasi-experimental study. A probability consecutive sampling method was used. Sixty-five women with a diagnosis of 1 to 2 uterine leiomyomas measuring 4– 8 cm in diameter, vitamin D insufficiency and experiencing heavy vaginal bleeding were included. The 25-hydroxyvitamin D levels in the blood were checked. Vitamin D was then administered in five dosages over a period of ten weeks, with each patient receiving a total dose of 50,000 IU of vitamin D after every fourteen days. After 6 months, an ultrasound was done to determine the size of the fibroid. The mean size of leiomyomas was compared before and after vitamin D for six months using a paired t-test.
Results: Mean age of the patients was 35.85±6.140 year. Mean age at menarche of the patients was 11.62±1.206 year. Mean marital life of the patients was 9.47±6.046 year. Mean Hb levels of the patients were 11.406±1.1875 mg/dl. Mean size of leiomyoma before treatment was 54.170±4.5493 mm, while mean size of leiomyoma after treatment was 44.991±2.7046 mm, with a p-value of 0.001.
Conclusion: Vitamin D supplementation has been demonstrated to considerably reduce the growth of uterine fibroids. It would seem that females with vitamin D insufficiency can effectively treat their uterine fibroids by taking vitamin D supplements.