DefinePK

Abstract

Biofilms are bacterial colonies that adhere to surfaces, forming protective barriers against immune responses and antibiotics, which contribute to the development of chronic infections, particularly in medical implants. This study aims to investigate the factors that influence biofilm formation on medical implants and evaluate current strategies for preventing biofilm-related infections. A review of the literature on biofilm formation mechanisms, including quorum sensing and recalcitrance, was conducted, focusing on intrinsic (e.g., quorum-sensing molecules, c-di-GMP) and extrinsic factors (e.g., temperature, surface properties).  Biofilm-related infections are common in medical devices, complicating treatment and contributing to increased mortality. New strategies, including antimicrobial peptides, quorum-sensing inhibitors, and nanotechnology-based approaches, show promise in preventing biofilm formation. Surface modifications, such as antibiotic-loaded and nano-silver coatings, significantly reduce bacterial adhesion. Despite progress in biofilm prevention, further research is necessary to refine strategies for controlling implant-related infections and improving patient outcomes.