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Abstract

Hyperthyroidism, characterized by the overproduction of thyroid hormones, may impact liver function. Understanding this relationship is essential for early identification and management of liver dysfunction in hyperthyroid patients. Objectives: To determine the association between thyroid hormone levels (TSH, T3, T4) and liver function tests (ALT, AST, ALP, bilirubin, and total protein) in patients with hyperthyroidism.
Methods: This cross-sectional study was conducted from 28 July 2023 to 28 January 2024 at the Endocrinology OPD of Gulab Devi Hospital, Lahore. A total of 100 hyperthyroid patients were selected using non-probability sampling. Demographic data, thyroid profiles (T3, T4, TSH), and liver function tests (LFTs) were recorded. Data were analyzed by SPSS version 26.0 using descriptive statistics and Chi-square tests to assess associations. Results: Out of 100 hyperthyroid patients, 59 were female and 41 were male, with a mean age of 38.5 + 10.2 years. Elevated ALT was observed in 27% of patients, AST in 13%, ALP in 23%, bilirubin in 13%, and total protein in 11%. Chi-square analysis showed significant associations between TSH and ALT (p=0.028) and AST (p=0.017), as well as between T3 and ALP (p=0.031). No significant associations were found between T4 and any of the liver enzymes. Conclusions: A significant proportion of hyperthyroid patients showed abnormal LFTs, indicating a relationship between thyroid dysfunction and hepatic involvement. Further large-scale studies are recommended