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Abstract

Background: Breast cancer is the most prevalent cancer type in females worldwide. Currently, radiological imaging plays an important role in early diagnosis of breast cancer including ultrasonography, Mammography and Magnetic Resonance Imaging (MRI) examination.Objective: To determine the diagnostic accuracy of BIRADS score of ≥ IV on mammography for the detection of malignant breast lesions by taking histopathology as gold standard in patients presenting with breast lump at a Tertiary Care Hospital.Materials and Methods: A cross-sectional prospective study was conducted in the Department of Radiology at Dr. Ziauddin University Hospital, Karachi from January 2023 to December 2023. A total of 187 patients presenting with breast lumps were included in this study. Brief history for demographic information was taken. Mammography was performed in all patientsand the breast lump was classified according to the BIRADS scoring system. The histopathological correlation of breast lesions was taken as gold standard. All information were entered in performa and statistical analysis was done using SPSS version 25.Results: The average age of the patient was 50.04±7.85 years. Sensitivity, specificity, PPV, NPV and accuracy of BIRADS score ≥ IV on mammography for the detection of malignant breast lesions were 94.1%, 89%, 76.2%, 97.6% and 90.3% respectively.Conclusion: Taking BI-RADS grade 4A or higher as the positive standard, the sensitivity of mammography in diagnosing breast cancer was 90.3%; therefore, it is an effective tool and noninvasive method for early detection of breast cancer.Key Words: Breast cancer, BI-RADS grading, Breast lump, Mammography, Malignant, Benign.