DefinePK

Abstract

Background: Benign prostatic enlargement (BPE) is frequently observed in aging men. An association exists between lower urinary tract symptoms (LUTS) and sexual dysfunction resulting from BPE.
Objective: To compare the effect of Tamsulosin alone and Dutasteride in combination with Tamsulosin on men’s sexual
function (ejaculatory function, libido) for managing LUTS secondary to BPE.
Method: This quasi-experimental study was carried out at department of Urology, Nishtar Hospital Multan (2021-22) on 138 BPE patients in 2 equal groups. Group A was given Tamsulosin (0.4mg) and group B received combination of Tamsulosin and Dutasteride (0.4mg/0.5mg) at bedtime. Patients were followed in OPD at 3, 6, 9 and 12 months of study and each patient filled questionnaires on every visit of international prostate scoring system (IPSS), International Index of Erectile Function (IIEF-5) and Premature Ejaculation diagnostic tool (PEDT) to assess the sexual adverse effects. Data was analyzed in SPSS v25 using t-test for quantitative and chi-square for qualitative variables; p ? 0.05 was considered significant. Ethical approval was obtained from institutional committee.
Results: Mean IPSS score in group A was 9.63±2.69 and in group B was 7.57±2.18 (p-value=<0.001). The mean Erectile dysfunction score in group A was 15.78±3.17 and in group B was 9.29±1.76 (p-value=<0.001). The mean ejaculation dysfunction score in group A was 8.92±2.19 and in group B was 12.39±2.02 (p-value=<0.001).
Conclusion: While treating LUTS in patients with BPE, although combination therapy of Tamsulosin and Dutasteride is better, it has significant adverse effects on sexual activity compared to Tamsulosin monotherapy.