DefinePK

Abstract

Background: Convulsive disorders often present as urgent neurological conditions requiring prompt intervention like IV midazolam. However, establishing an IV line especially in the ER can delay treatment institution. Therefore, rectal, buccal and intramuscular routes for administration are considered in such cases. Objective of this study was to compare the mean time for control of acute seizures by using buccal and intravenous midazolam in children. Method: This was a quasi experimental study carried over 6 months in the Paediatric Accident and Emergency Department, PAF Hospital, Mushaf, Sargodha. The study included a total of 60 children in actively fitting state. The subjects were divided into 2 groups of 30 in each, Group A having buccal midazolam and Group B having IV midazolam for control of seizure episode. Repeat dose was given after 5 minutes if seizures were not controlled. Time required to control seizures was noted for each patient. Results: Patients included in study had a mean age of 3.93±3.05 years, with 28 (46.6%) males and 32 (53.33%) female patients. Forty-seven (78.33%) had generalized seizures and 13 (21.67%) had partial seizures. Mean time for control of seizures was 198.33±133.19 seconds in Group A and 169.73±115.22 seconds in Group B. The difference was statistically insignificant with p=0.377. Conclusion: Buccal midazolam is an effective method for controlling acute seizures in children. It can be used as first line therapy instead of intravenous midazolam in pre-hospital and emergency settings.
Pak J Physiol 2025;21(3):18–21, DOI: https://doi.org/10.69656/pjp.v21i3.1832