DefinePK

Abstract

Deficiency of vitamin D (25-hydroxycholecalciferol) has long been concerned in activation of tuberculosis (TB). Pakistan stands fifth among 22 countries that have the highest TB incidence. Vitamin D influences the immune response to tuberculosis and vitamin D deficiency has been associated with increased risk of tuberculosis in different populations. This study was designed to show the relationship between vitamin D level (deficiency) and risk of tuberculosis. Eighty five blood samples of tuberculosis patients were taken from District Head Quarter (DHQ) Hospital, Sargodha. ORGENTEC ELISA Kit was used for vitamin D quantification.  Mean vitamin D level were 13.9± 1.68 ng/mL in control and 9.3 ±1.38 ng/mL in TB patients. Out of 85 patients 82 patients showed vitamin D level less than 12 ng/mL. Vitamin D deficiency was seen in almost 96% of patients as compared to control. Female patients (9.05±1.55 ng/mL) also have significantly lower vitamin D level as compare to male patients (9.79±1.34 ng/mL). These findings warrant further studies that the vitamin D supplementation may have the role in the treatment and prevention of tuberculosis.
Keywords:  ELISA; Pakistan; Tuberculosis; Vitamin D
http://dx.doi.org/10.19045/bspab.2018.70028