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Abstract

The current study was carried out on a crude extract of stem of Periploca aphylla. It is found in the regions of Jhal magsi, Khuzdar and Pujgur in Balochisatn. P. aphylla has numerous therapeutic uses in traditional medicine. It is used for the relief of pain, ulcer, skin disorders, tumors and for extensive range of other diseases. In neuropharmacological studies mice treated with the crude extract of P. aphylla showed sedative effects in open field, cage crossing, traction and rearing test particularly at the dose of 500 mg/kg as compared with standard drug diazepam. In force induced swiming test increase in immobility time was observed at the dose of 250 and 500 mg/kg. Results were significantly comparable with standard drug diazepam. The administration of the crude extract of P. aphylla produced significant analgesic effects particularly at the dose of 500 mg/kg in the acetic acid induced writhing test and the formalin test. In conclusion, results suggests that the methanolic extract of P. aphylla possesses sedative effects and potent analgesic effects.
keywords: Analgesic; Periploca aphylla; Sedative
http://dx.doi.org/10.19045/bspab.2016.50145