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Abstract

Attenuation of hyperlipidemia with extract of medicinally important plant and reversal of lipid disorders is clinically very important. The aim of present study was to identify the therapeutic potential of Solanum nigrum ethanolic extract in lowering the cholesterol level in lipofundin treated hyperlipidimic rabbits in vivo. 20% lipofundin was used to induce hyperlipidmia in rabbits @ 2 ml/kg body weight through slow intravenous administration in the marginal ear vein for 7 days. For next 2 weeks the control group was placed at standard diet, whereas the test group was given the ethanolic crude extract of Solanum nigrum at the dose of 300 mg/kg body weight. On the completion of treatment blood samples were collected from both control and test groups and were analyzed for the lipid profile values. It was observed in the test group after treatment with ethanolic extract of S. nigrum, the raised level of serum total cholesterol, triglyceride, high-density lipoprotein, low-density lipoprotein were decreased towards normal values. Thus the present study demonstrated that S. nigrum possessed significant anti-hyper lipidimic activity in lipofundin induced hyperlipidimic rabbits.
Keywords: Hyperlipidemia; Lipid profile; Medicinal plants; Solanum nigrum; Ethanolic extract
http://dx.doi.org/10.19045/bspab.2016.50011