DefinePK hosts the largest index of Pakistani journals, research articles, news headlines, and videos. It also offers chapter-level book search.
Title: Antihyperlipidemic, hypoglycaemic and antioxidative potential of Juglans Regia (walnuts) in an experimental animal model of dietary hyperlipidemia.
Authors: Iqra Sangi, Mufzala Shamim, Nazish Iqbal Khan
Journal: International Journal of Endorsing Health Science Research
Publisher: Advance Educational Institute & Research Centre
Country: Pakistan
Year: 2022
Volume: 10
Issue: 1
Language: English
Keywords: Juglans RegiaWalnutHyperlipidemiaHyperglycemiaCardioprotective Antioxidant Potential.
Background: Cardiovascular diseases (CVD) are recognized as the world's primary cause of fatality, particularly in the developing countries. Stroke and ischemic heart disease have reportedly been the principal manifestations of vascular disease mainly because of the gradual increase in the incidence of the risk factors. In this aspect, the present study is planned to investigate the cardio-protective potential of Juglans regia (JR) (walnuts) consumption in controlling dyslipidemia. JR has notable therapeutic effects and, it has been used since ancient times for its anti-inflammatory, cardio-protective, and anti-bacterial properties.
Methodology: In this study, 32 age-matched females, Wistar albino rats of 5-6 weeks weighing 200 g, were selected and equally divided into four experimental groups. Group I was used as control, Group II was positively induced hyperlipidemia through a high-fat diet; Group III animals were fed normal rat chow along with 153 mg JR powder, and Group IV animals have also inducted hyperlipidemia through a high-fat diet incorporated with 153 mg JR powder/Kg for 15 days. Bodyweight changes along with daily diet consumption were measured on alternate days.
Results: In comparison to the control group, animals fed with a high-fat diet (Group II) showed a non-significant increase in plasma lipid profile, total cholesterol (TC), triglycerides (TG), and plasma high-density lipoprotein (HDL) levels. Group III and IV animals, after walnut powder supplementation, showed a significant decrease in lipid profile change in very Low-Density Lipoprotein levels (VLDL) of 10.3 ± 0.60 mg/dl and 12.27 ± 0.94 mg/dl together with nephron-protective & reno-protective enzymatic alterations. Histological analysis revealed signs of inflammation in high fat treated groups while well-maintained cardiac tissues within walnut treated groups, respectively.
Conclusion: Daily consumption of Juglans Regia (walnut) in the dosage mentioned earlier is beneficial in protectively modulating dyslipidemia, hyperglycemic, and oxidative tissue potential of high-fat diet consumption in an experimental animal model.
To investigate the cardio-protective potential of Juglans regia (walnuts) consumption in controlling dyslipidemia, and its antihyperlipidemic, hypoglycemic, and antioxidative effects in an experimental animal model of dietary hyperlipidemia.
Thirty-two age-matched female Wistar albino rats (5-6 weeks old, weighing 200g) were divided into four groups: Group I (control, normal rat chow), Group II (hyperlipidemic, high-fat diet), Group III (walnut powder with normal rat chow), and Group IV (walnut powder with high-fat diet). Bodyweight and diet consumption were monitored. Biochemical analysis of plasma lipid profiles, liver enzymes, and histological examination of heart tissues were performed.
graph TD
A[Animal Selection & Acclimatization] --> B[Group Allocation];
B --> C[Diet Preparation];
C --> D[Experimental Period 15 days];
D --> E[Data Collection];
E --> F[Biochemical Analysis];
E --> G[Histopathological Examination];
F --> H[Statistical Analysis];
G --> H;
H --> I[Results Interpretation];
I --> J[Discussion & Conclusion];
The study suggests that Juglans Regia (walnut) possesses significant antihyperlipidemic and antioxidant properties, likely due to its rich content of polyunsaturated fatty acids (PUFAs), polyphenols, and vitamin E. Walnut consumption helped modulate dyslipidemia, reduce oxidative stress, and protect cardiac and hepatic tissues in rats fed a high-fat diet.
High-fat diet induced hyperlipidemia in Group II rats, showing increased body weight and elevated plasma levels of LDL-C, VLDL-C, and atherogenic index, along with increased liver enzymes (AST, ALT, ALP) and lymphocytic infiltration in heart tissues. Walnut supplementation in Groups III and IV led to a significant decrease in lipid profile parameters (LDL-C, VLDL-C, TC, TG), reduced liver enzyme levels, and improved heart tissue histology, with Group IV showing a notable reduction in hyperlipidemic markers compared to Group II.
Daily consumption of Juglans Regia (walnut) at the tested dosage is beneficial in protectively modulating dyslipidemia, hyperglycemic, and oxidative tissue potential in an experimental animal model of dietary hyperlipidemia, suggesting its potential role in limiting or delaying pathological changes associated with cardiovascular diseases.
1. Number of Rats: 32 female Wistar albino rats were used in the study. (Confirmed in Methodology)
2. Walnut Dosage: 0.153g of walnut powder per rat per day was administered to Groups III and IV. (Confirmed in Methodology and Results)
3. Study Duration: The experimental period was 15 days. (Confirmed in Methodology and Results)
Loading PDF...
Loading Statistics...