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Abstract

Objective: To advance our understanding of the integral nuclear protein's role in cell interaction and their capacity as diagnostic and therapeutic targets in oral cancer treatment. Methodology: This review was conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. The data of our systematic review were collected from six search engines i.e HEC Digital Library, PubMed/Medline, Elsevier, Wiley Online Library, Google Scholar and Wolter Kluwer, from the year 2014 to 2024. In order to conduct this review, studies selection was done based on the following criteria which includes Articles with Abstract containing integral nuclear proteins Cell signaling and Oral cancer, Top fifty most cited articles based on their citation count and articles containing role of Integral nuclear proteins in cancer treatment. Results: In order to carry out this study, forty studies were searched and assessed which discussed the role of integral nuclear proteins in cell signaling and recent advancements describing the application of these proteins as a diagnostic tool in oral cancer detection and prevention. Conclusion: This systematic review describes the application of role of integral nuclear protein plays in pathophysiology of Oral cancer and that it can be used as a diagnostic parameter as well as treatment for oral cancer. However, this review did not discuss regarding the individual proteins role in cancer treatment and their use as a diagnostic and preventive tool such as role of YAP (Yes-associated protein) and p53.This research may have missed some studies written in language other than English..