Association Between Helicobacter Pylori Infection and Vitiligo

Article Information

Title: Association Between Helicobacter Pylori Infection and Vitiligo

Journal: Pakistan Armed Forces Medical Journal (PAFMJ)

HEC Recognition History

Category	From	To
Y	2024-10-01	2025-12-31
Y	2023-07-01	2024-09-30
Y	2021-07-01	2022-06-30
Y	2020-07-01	2021-06-30
Y	1900-01-01	2005-06-30

Publisher: Army Medical College, Rawalpindi.

Country: Pakistan

Year: 2024

Volume: 74

Issue: 5

Language: English

Keywords: EtiologyHelicobacter pyloriPathogenesisVitiligo.

Abstract

Objective: To determine the association between Helicobacter pylori infection and vitiligo in patients visiting a tertiary care hospital of Punjab, Pakistan.
Study Design: Case control study.
Place and Duration of Study: Department of Dermatology, Combined Military Hospital, Lahore Pakistan, from Oct 2021 to Mar 2022.
Methodology: A total of 60 adult vitiligo patients and 60 healthy controls, of both genders, were included in the study. Their ages ranged from 18-70 years. All study participants underwent stool antigen test to detect the presence of Helicobacter pylori antigen.
Results: The mean age of the cases was 43.47±8.16 years whereas it was 40.08±7.42 years in the controls. The mean duration of disease was 4.133±1.21 months. H. pylori Infection was detected in 36(60%) cases as compared to 11(18.3%) controls (p&lt;0.001, OR=6.68); which was found to be statistically significant.
Conclusion: Significant association between H. pylori infection and vitiligo was demonstrated in the current study.

Disclaimer: The following sections are produced through an intensive multi-stage analytical pipeline developed by DefinePK, utilizing advanced natural-language processing, domain-specific knowledge models, and automated cross-referencing systems. Despite the rigor and computational effort involved, the generated summary may still contain inaccuracies or incomplete interpretations. Users are strongly advised to verify all critical information against the original paper and its authoritative sources.

Research Objective

To determine the association between Helicobacter pylori infection and vitiligo in patients visiting a tertiary care hospital of Punjab, Pakistan.

Methodology

Case-control study conducted at the Department of Dermatology, Combined Military Hospital, Lahore, Pakistan, from October 2021 to March 2022. Sixty adult vitiligo patients and 60 healthy controls underwent a stool antigen test to detect Helicobacter pylori.

Methodology Flowchart

                        graph TD
A["Study Design: Case-Control"] --> B["Participants: 60 Vitiligo Cases, 60 Healthy Controls"];
B --> C["Stool Antigen Test for H. pylori"];
C --> D["Data Analysis"SPSS""];
D --> E["Results: Association between H. pylori and Vitiligo"];
E --> F["Conclusion: Significant Association Demonstrated"];

Discussion

The study discusses the conflicting data regarding the association of H. pylori infection with vitiligo and references other studies with varying results. It also touches upon the potential of H. pylori eradication therapy as a treatment for vitiligo.

Key Findings

H. pylori infection was detected in 60% of vitiligo cases compared to 18.3% of controls (p<0.001, OR=6.68), which was statistically significant.

Conclusion

The study demonstrated a statistically significant association between H. pylori infection and vitiligo.

Fact Check

1. The study was conducted from October 2021 to March 2022. (Confirmed by the Methodology section)
2. H. pylori infection was detected in 60% of cases and 18.3% of controls. (Confirmed by the Results section)
3. The sample size was 60 cases and 60 controls. (Confirmed by the Methodology section)

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