Comparison of Efficacy of Topical Cprofloxacin Ear Drops 0.6% Versus Oral Cprofloxacin 500 mg Twice Daily in Achieving Dry Ear in Chronic Suppurative Otitis Medi

Article Information

Title: Comparison of Efficacy of Topical Cprofloxacin Ear Drops 0.6% Versus Oral Cprofloxacin 500 mg Twice Daily in Achieving Dry Ear in Chronic Suppurative Otitis Medi

Authors: Muhammad Imran Malik, Aiman Fatima Naqvi, Zaimal Shahan, Amir Akbar, Amna Enam, Mohsin Raza

Journal: Pakistan Armed Forces Medical Journal (PAFMJ)

HEC Recognition History

Category	From	To
Y	2024-10-01	2025-12-31
Y	2023-07-01	2024-09-30
Y	2021-07-01	2022-06-30
Y	2020-07-01	2021-06-30
Y	1900-01-01	2005-06-30

Publisher: Army Medical College, Rawalpindi.

Country: Pakistan

Year: 2024

Volume: 74

Issue: 4

Language: English

Keywords: Anti-bacterial agentsCprofloxacinSuppurative otitis mediaSuppuration.

Abstract

Objective: To compare the efficacy of Cprofloxacin 0.6% ear drops versus oral Cprofloxacin in achieving the dry ears in chronic suppurative otitis media patients presenting at a tertiary care hospital, Islamabad Pakistan.
Study Design: Quasi-experimental study.
Place and Duration of Study: Department of Otorhinolaryngology and Head and Neck Surgery, Pakistan Institute of Medical Sciences, Islamabad Pakistan, from Jun 2022 to Dec 2022.
Methodology: The study recruited 130 patients with unilateral or bilateral chronic ear discharge, of either gender, aged 12-60 years, and divided them into two groups of 65 each. Group-A received topical Cprofloxacin 0.6% in a dose of four drops three times per day, while Group-B, 65 patients received oral Cprofloxacin 500 mg twice daily. Otoscopy was used to monitor patients for two weeks following dry ear treatment.
Results: The mean age of participants was 29.70±9.03 years and most patients were males (60%). Post-treatment results of Group-A revealed that there were 11(16.9%) subjects with ear discharge. The rest 54(83.1%) had no ear discharge. In Group-B, there were 46(70.8%) subjects with ear discharge. The rest 19(29.2%) had no ear discharge. A statistically significant (p=0.001) difference in efficacy was observed between both groups.
Conclusion: Topical Cprofloxacin 0.6% given 6 drops twice daily for two weeks is a better choice in medical management of CSOM than oral Cprofloxacin 500mg twice daily in terms of resolution of ear discharge.

Disclaimer: The following sections are produced through an intensive multi-stage analytical pipeline developed by DefinePK, utilizing advanced natural-language processing, domain-specific knowledge models, and automated cross-referencing systems. Despite the rigor and computational effort involved, the generated summary may still contain inaccuracies or incomplete interpretations. Users are strongly advised to verify all critical information against the original paper and its authoritative sources.

Research Objective

To compare the efficacy of Cprofloxacin 0.6% ear drops versus oral Cprofloxacin in achieving dry ears in chronic suppurative otitis media (CSOM) patients.

Methodology

Quasi-experimental study involving 130 patients with chronic ear discharge, divided into two groups of 65. Group-A received topical Cprofloxacin 0.6% ear drops (four drops three times per day), and Group-B received oral Cprofloxacin 500 mg twice daily for two weeks. Patients were monitored via otoscopy for two weeks.

Methodology Flowchart

                        graph TD;
    A["Recruit 130 CSOM patients"] --> B["Divide into two groups"65 each""];
    B --> C["Group-A: Topical Cprofloxacin ear drops"];
    B --> D["Group-B: Oral Cprofloxacin"];
    C --> E["Administer treatment for 2 weeks"];
    D --> E;
    E --> F["Monitor patients via otoscopy"];
    F --> G["Analyze results: % of dry ears"];
    G --> H["Compare efficacy between groups"];
    H --> I["Conclude topical Cprofloxacin is more effective"];

Discussion

Topical Cprofloxacin 0.6% ear drops were found to be more efficacious than oral Cprofloxacin 500 mg twice daily in resolving ear discharge in CSOM patients. This aligns with international research suggesting topical quinolone antibiotics are more effective than systemic ones for this condition.

Key Findings

After two weeks, 83.1% of patients in Group-A (topical Cprofloxacin) achieved dry ears, compared to 29.2% in Group-B (oral Cprofloxacin). This difference was statistically significant (p=0.001).

Conclusion

Topical Cprofloxacin 0.6% administered as six drops twice daily for two weeks is a superior choice for the medical management of CSOM compared to oral Cprofloxacin 500 mg twice daily, in terms of achieving dry ears.

Fact Check

1. Study Duration: The study was conducted from June 2022 to December 2022. (Confirmed)
2. Sample Size: 130 patients were recruited and divided into two groups of 65 each. (Confirmed)
3. Efficacy of Topical Cprofloxacin: 83.1% of patients receiving topical Cprofloxacin achieved dry ears. (Confirmed)

Mind Map

Loading PDF...

Loading Statistics...

DefinePK

Select Collection