DefinePK

Research Objective

To compare the efficacy of 5% Permethrin with oral Ivermectin for the management of scabies.

Methodology

Quasi-experimental study involving 100 patients aged 5-80 years. Participants were randomly assigned to two groups: Group A received Permethrin 5% twice with a one-week interval, and Group B received a single dose of oral Ivermectin. Evaluation was conducted at 2-4 week intervals.

Methodology Flowchart

                        graph TD;
    A["Enroll 100 Patients"] --> B["Random Assignment"];
    B --> C["Group A: Permethrin 5%"];
    B --> D["Group B: Oral Ivermectin"];
    C --> E["Administer Treatment"];
    D --> E;
    E --> F["Evaluate at 2-4 Weeks"];
    F --> G["Analyze Results"];
    G --> H["Compare Efficacy"];
    H --> I["Draw Conclusions"];                    

Discussion

Permethrin 5% demonstrated better efficacy and compliance as a first-dose treatment for scabies compared to oral Ivermectin. While Permethrin showed faster symptom improvement, oral Ivermectin was noted as useful for severely crusted lesions and immunocompromised patients, often requiring a second dose.

Key Findings

In Group A (Permethrin 5%), 86% of patients showed symptom improvement, compared to 48% in Group B (oral Ivermectin). There was a statistically significant relationship between Permethrin and Ivermectin (p-value < 0.001).

Conclusion

Permethrin is more effective than Ivermectin at first-dose response and offers better compliance and safety for scabies patients.

Fact Check

* The study enrolled 100 patients.
* Permethrin 5% showed symptom improvement in 86% of patients.
* Oral Ivermectin showed symptom improvement in 48% of patients.

Mind Map