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Title: Early Complications of Surfactant Administration In Neonates
Authors: Hafiz zulqar nain, Muhammad Tariq Nadeem, Sammar Hussain, Ali Mujtaba, Saeed Zaman, Waleed Ali
Journal: Pakistan Armed Forces Medical Journal (PAFMJ)
Publisher: Army Medical College, Rawalpindi.
Country: Pakistan
Year: 2024
Volume: 74
Issue: 3
Language: English
Keywords: BradycardiaComplicationsNeonatesSurfactantPulmonary hemorrhage
Objective: To assess the early complications of surfactant administration in neonates with respiratory distress syndrome.
Study Design: Perspective longitudinal study.
Place and Duration of Study: Pak Emirates Military Hospital (PEMH), Rawalpindi Pakistan, from Jun to Dec 2021.
Methodology: A total of 64 neonates admitted in ICU with gestational age 27-32 weeks requiring Continuous Positive Airway Pressure and surfactant administration were included. Neonatal complications after 24 hours of administration of surfactant and final outcome was recorded on a predesigned data collection tool.
Results: Mean duration of stay on ventilator was 41.12±8.88 hours. Mean duration for Continuous Positive Airway Pressure was 43.59±22.70 hours. Second dose of surfactant was given to 34(53.1%) of neonates. Among neonates 25% suffered from pulmonary hemorrhage and 7.8% from bradycardia, 48(75%) were discharged and 16(25%) died.
Conclusion: The mortality rate decreased in neonates after administration of surfactant. In future, we will implement surfactant in term neonates, diagnosed with Respiratory Distress Syndrome, in order to improve the survival of neonates and reduce complications.
To assess the early complications of surfactant administration in neonates with respiratory distress syndrome (RDS).
Prospective longitudinal study conducted at Pak Emirates Military Hospital, Rawalpindi, from June to December 2021. Included 64 neonates (27-32 weeks gestational age) with RDS requiring CPAP and surfactant. Neonatal complications were recorded 24 hours post-surfactant administration.
graph TD
A[Ethical Approval] --> B[Patient Enrollment];
B --> C[Inclusion/Exclusion Criteria Met?];
C -- Yes --> D[Surfactant Administration & CPAP];
D --> E[Monitor for 24 Hours];
E --> F[Record Complications];
F --> G[Data Analysis];
G --> H[Results];
H --> I[Conclusion];
C -- No --> J[Exclude Patient];
The study discusses the complications of surfactant administration, including bradycardia, hypotension, and pulmonary hemorrhage. It compares the findings with existing literature, highlighting the potential risks and benefits of surfactant therapy.
Mean ventilator duration was 41.12±8.88 hours, and CPAP duration was 43.59±22.70 hours. 53.1% required a second surfactant dose. 25% experienced pulmonary hemorrhage, 7.8% bradycardia. The discharge rate was 75%, and the mortality rate was 25%.
Surfactant administration in neonates with RDS improved survival outcomes and reduced complications. It can be implemented as a supportive treatment in neonatal facilities to reduce neonatal mortality.
1. Study period: June to December 2021 - Confirmed by the Methodology section.
2. Sample size: 64 neonates - Confirmed by the Methodology and Results sections.
3. Pulmonary hemorrhage rate: 25% - Confirmed by the Results section.
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