Uric Acid/ HDL Ratio as a Marker of Disease in Coronary Artery Ectasia Versus Normal Coronaries

Article Information

Title: Uric Acid/ HDL Ratio as a Marker of Disease in Coronary Artery Ectasia Versus Normal Coronaries

Authors: Maida Anwar, Asif Nadeem, Muhammad Bilal Siddique, Fahad Khan Toru, Asma Zafar Khawaja, Sarwat Paiker Malik, Javeria Kamran, Naseem Azad

Journal: Pakistan Armed Forces Medical Journal (PAFMJ)

HEC Recognition History

Category	From	To
Y	2024-10-01	2025-12-31
Y	2023-07-01	2024-09-30
Y	2021-07-01	2022-06-30
Y	2020-07-01	2021-06-30
Y	1900-01-01	2005-06-30

Publisher: Army Medical College, Rawalpindi.

Country: Pakistan

Year: 2024

Volume: 74

Issue: Supplementary 1

Language: English

Keywords: Coronary artery ectasiaUnobstructed coronariesUric Acid/HDL Ratio

Abstract

Objective: To determine the strength of association of raised uric acid/ High-Density Lipoprotein ratio in patients with Coronary Artery Ectasia versus normal coronaries.
Study Design: Analytical Cross-sectional study.
Place and Duration of Study: Armed Forces Institute of Cardiology/National Institute of Heart Diseases, Rawalpindi, Dec 2022 to May 2023
Methodology: Total n=146 patients aged between 20-90 years of both gender, with chest pain who had CAE or unobstructed coronaries on coronary angiography, and normal heart structure and valvular function were included. Patients were divided into two groups: those with Coronary Artery Ectasia (Group-I) and those without Coronary Artery Ectasia (Group-II). Serum uric acid and High-Density Lipoprotein level were measured for each patient and their ratio was calculated. Qualitative variables were compared across groups using the Chi-square test/Fischer Exact test, while quantitative variables were compared using the independent samples t-test. Univariate and multivariate logistic regression analysis was used to predict the odds ratio to show association between predictors and outcome (Coronary Artery Ectasia) and p&lt;0.05 was considered as statistically significant
Results: Study sample n=146 had mean age of 52.83 ± 9.67 years, comprised of 113(77.4%) males and 33(22.6%) females. Uric acid to HDL ratio above 0.12 had an adjusted odds ratio (aOR) of 9.3 (CI 95% 3.3–26.0) for having Coronary artery ectasia (p&lt;0.001). Males and age of 60 years or greater were also associated with an increased odds, with (aORs) of .....
Conclusion: Uric acid/HDL ratio is a useful variable in predicting odds of coronary artery ectasia in patients with chest pain.

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Research Objective

To determine the strength of association of raised uric acid/ High-Density Lipoprotein ratio in patients with Coronary Artery Ectasia versus normal coronaries.

Methodology

Analytical cross-sectional study conducted from Dec 2022 to May 2023 at Armed Forces Institute of Cardiology/National Institute of Heart Diseases, Rawalpindi. Included 146 patients (73 with CAE, 73 controls) aged 20-90 years with chest pain, normal heart structure, and valvular function. Serum uric acid and HDL levels were measured, and the ratio was calculated. Statistical analysis included Chi-square test/Fischer Exact test for qualitative variables and independent samples t-test for quantitative variables. Logistic regression was used to predict odds ratios.

Methodology Flowchart

                        graph TD
A[Patients with Chest Pain] --> B[Coronary Angiography];
B -- CAE Present --> C[CAE Group n=73];
B -- Unobstructed Coronaries --> D[Control Group n=73];
C & D --> E[Blood Sample Collection Uric Acid, HDL];
E --> F[Uric Acid/HDL Ratio Calculation];
F --> G[Statistical Analysis];
G --> H[Results: Odds Ratio Calculation];
H --> I[Conclusion: UHR as Predictor of CAE];

Discussion

The study investigated the potential use of UHR as a predictor of CAE. High UHR levels predict CAE. The most common artery affected was the right coronary artery (33.6%).

Key Findings

Uric acid to HDL ratio above 0.12 had an adjusted odds ratio (aOR) of 9.3 (CI 95% 3.3-26.0) for having Coronary artery ectasia (p<0.001). Males and age of 60 years or greater were also associated with an increased odds, with (aORs) of 4.0(CI 95% 1.2-13.1) and 2.8(CI 95% 1.0-8.3) (p<0.001), respectively.

Conclusion

Serum UHR is a clinically useful measure for assessing the odds of CAE presence.

Fact Check

1. Study period: Dec 2022 to May 2023 - Confirmed in Methodology section.
2. Sample size: n=146 - Confirmed in Methodology and Results sections.
3. aOR for UHR > 0.12: 9.3 (CI 95% 3.3-26.0) - Confirmed in Results section.

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