Frequency of Subclinical Hypothyroidism in Patients with First-Trimester Pregnancy Loss

Article Information

Title: Frequency of Subclinical Hypothyroidism in Patients with First-Trimester Pregnancy Loss

Authors: Saleha Hassan, Rabiya Akbar, Uzma Urooj, Sadaf Zohra, Nusrat Noor

Journal: Pakistan Armed Forces Medical Journal (PAFMJ)

HEC Recognition History

Category	From	To
Y	2024-10-01	2025-12-31
Y	2023-07-01	2024-09-30
Y	2021-07-01	2022-06-30
Y	2020-07-01	2021-06-30
Y	1900-01-01	2005-06-30

Publisher: Army Medical College, Rawalpindi.

Country: Pakistan

Year: 2023

Volume: 73

Issue: 5

Language: English

DOI: 10.51253/pafmj.v73i5.7432

Keywords: Early pregnancy lossMiscarriagesThyroid disorders

Abstract

Objectives: To determine the frequency of subclinical Hypothyroidism in women with first-trimester pregnancy loss.
Study Design: Cross-sectional study.
Place and Duration of Study: Gynaecology &amp; Obstetrics Department, Combined Military Hospital, Rawalpindi Pakistan,from Jun 2018 to Dec 2018.
Methodology: The study included 130 women aged 18-40 years who had first-trimester pregnancy loss. Patients withchronic renal failure, known thyroid disorders and taking medication that can affect thyroid functions were excluded. Venous blood samples were taken to analyse thyroid function tests, and subclinical Hypothyroidism was noted.
Results: The mean age of the women was 28.68±4.80 years. Most patients 77(59.23%), were between 18 and 30 years old. The mean BMI was 29.42±2.50 kg/m2. 16(12.31%) women with first-trimester miscarriage had subclinical Hypothyroidism.
Conclusion: This study concluded that the frequency of subclinical Hypothyroidism in women with first-trimester pregnancy loss was significant. Proper management protocol for early recognition and management of subclinical Hypothyroidism in women can improve pregnancy outcomes.

Disclaimer: The following sections are produced through an intensive multi-stage analytical pipeline developed by DefinePK, utilizing advanced natural-language processing, domain-specific knowledge models, and automated cross-referencing systems. Despite the rigor and computational effort involved, the generated summary may still contain inaccuracies or incomplete interpretations. Users are strongly advised to verify all critical information against the original paper and its authoritative sources.

Research Objective

To determine the frequency of subclinical Hypothyroidism in women with first-trimester pregnancy loss.

Methodology

Cross-sectional study conducted at the Gynaecology & Obstetrics Department, Combined Military Hospital, Rawalpindi, Pakistan, from June to December 2018. Included 130 women aged 18-40 years with first-trimester pregnancy loss. Excluded patients with chronic renal failure, known thyroid disorders, or those taking thyroid-affecting medications. Thyroid function tests were analyzed from venous blood samples to identify subclinical Hypothyroidism.

Methodology Flowchart

                        graph TD;
    A["Recruit 130 women with first-trimester pregnancy loss"] --> B["Apply Exclusion Criteria"];
    B -- Excluded --> C["Discard"];
    B -- Included --> D["Collect venous blood samples"];
    D --> E["Analyze thyroid function tests"];
    E --> F["Identify subclinical Hypothyroidism"];
    F --> G["Record data age, BMI, history, subclinical Hypothyroidism"];
    G --> H["Analyze data using SPSS"];
    H --> I["Report Key Findings and Conclusion"];

Discussion

The study suggests a significant frequency of subclinical Hypothyroidism in women experiencing first-trimester pregnancy loss. This condition is linked to adverse maternal and fetal outcomes, including increased risks of preterm birth, low birth weight, and miscarriage. Early recognition and management of subclinical Hypothyroidism are crucial for improving pregnancy outcomes.

Key Findings

16 (12.31%) women with first-trimester miscarriage had subclinical Hypothyroidism. The mean age of the participants was 28.68±4.80 years, and the mean BMI was 29.42±2.50 kg/m².

Conclusion

Subclinical Hypothyroidism is associated with early pregnancy loss. Implementing proper management protocols for early identification and treatment of subclinical Hypothyroidism in women with first-trimester miscarriages can help reduce the rate of these losses.

Fact Check

- The study included 130 women aged 18-40 years.
- 16.12% of women with first-trimester miscarriage were found to have subclinical Hypothyroidism.
- The study was conducted between June 2018 and December 2018.

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