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Title: Relationship of Peripheral Vestibular Deficits with Metabolic SyndromesAn Experience at CMH Q
Authors: Zeeshan Ayub, Azeema Ahmed, Irfan Saeed, Saima Bashir, Usman Afzal Malik, Hamid Iqbal
Journal: Pakistan Armed Forces Medical Journal (PAFMJ)
Publisher: Army Medical College, Rawalpindi.
Country: Pakistan
Year: 2023
Volume: 73
Issue: 4
Language: English
DOI: 10.51253/pafmj.v73i4.9588
Keywords: Diabetes mellitusHyperlipidemiasPeripheral vestibular diseases
Objective: To observe the association between metabolic syndromes and vestibular disturbances.
Study Design: Cross sectional study.
Place and Duration of Study: Departments of ENT & Pathology, Combined Military Hospital, Quetta Pakistan, from Apr 2020 to Jul 2022.
Methodology: The presence of diabetes mellitus and hyperlipidemias was studied in three hundred and twenty-seven cases of peripheral vestibular diseases. Vestibular disorders comprise benign paroxysmal positional vertigo, vestibular neuritis and Meniere’s disease.
Results: In three hundred twenty-seven cases evaluated, glycosylated haemoglobin was raised in 201(61.4%) cases (p-value of0.001), and serum lipid levels were elevated in 180(55%) cases (p-value=of 0.068).
Conclusion: Patients with diabetes mellitus have a significant chance of developing peripheral vestibular disorders.Keywords: Diabetes mellitus, Hyperlipidemias, Peripheral vestibular diseases.
To observe the association between metabolic syndromes and vestibular disturbances.
A cross-sectional study was conducted at the Departments of ENT & Pathology, Combined Military Hospital, Quetta, Pakistan, from April 2020 to July 2022. Three hundred and twenty-seven patients with peripheral vestibular diseases were evaluated for the presence of diabetes mellitus and hyperlipidemias. Glycosylated hemoglobin and serum lipid profiles were measured. Data was analyzed using SPSS version 25, with the chi-square test used for statistical significance (p-value < 0.05).
graph TD
A["Patient Recruitment n=327"] --> B["Inclusion/Exclusion Criteria Check"];
B --> C["Data Collection: Vestibular Assessment"];
C --> D["Blood Sample Collection"];
D --> E["Measurement of Glycosylated Hemoglobin"];
D --> F["Measurement of Serum Lipid Profile"];
E --> G["Data Analysis SPSS v25"];
F --> G;
G --> H["Statistical Significance"Chi-square test""];
H --> I["Results & Conclusion"];
The study suggests that metabolic disorders, particularly diabetes mellitus, are independent risk factors for peripheral vestibular disorders. While a significant association was found with elevated glycosylated hemoglobin, the association with raised serum lipid profile was not statistically significant in this study. The discussion reviews existing literature supporting the link between metabolic conditions and vestibular dysfunction, often attributed to microvascular damage and compromised blood supply to the vestibular system.
In the 327 cases evaluated, glycosylated hemoglobin was elevated in 201 (61.4%) cases (p=0.001), and serum lipid levels were elevated in 180 (55%) cases (p=0.068).
Patients with diabetes mellitus have a significant chance of developing peripheral vestibular disorders.
- Glycosylated hemoglobin was raised in 61.4% of cases. (Confirmed in Results)
- Serum lipid levels were elevated in 55% of cases. (Confirmed in Results)
- The study included 327 cases. (Confirmed in Methodology and Results)
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