DefinePK

Abstract

Bioactive compounds in foods are naturally occurring constituents that, beyond their basic nutritional value, exert beneficial effects on human health. These compounds, encompassing polyphenols, flavonoids, carotenoids, peptides, and phytosterols are widely distributed across plant and animal-based foods, fermented products, and agro-industrial by-products. This review comprehensively examines the diverse sources of bioactive compounds, highlighting key food matrices such as fruits, vegetables, cereals, dairy, meat, and fermented foods. Emphasis is placed on the chemical stability of these compounds, detailing how processing, storage, and environmental factors impact their integrity and bioavailability. Advanced preservation and delivery technologies, including encapsulation and nanoformulations, are explored for their roles in enhancing compound stability and functional efficacy. The health implications of bioactive compounds are critically discussed, with evidence from in vitro, in vivo, and clinical studies illustrating their antioxidant, anti-inflammatory, antimicrobial, and immunomodulatory properties. Particular focus is given to their potential roles in mitigating chronic diseases such as cardiovascular disorders, diabetes, and cancer. Furthermore, challenges relating to variability in compound composition, standardization, and regulatory frameworks are addressed. The review concludes with future perspectives, emphasizing the integration of bioactive compounds into functional foods, nutraceuticals, and personalized nutrition to promote public health. This synthesis provides valuable insights for researchers, food scientists, and health professionals aiming to harness bioactive compounds for disease prevention and health promotion.